Conserved Site

Profilin conserved site (IPR027310)

Short name: Profilin_CS


Profilin [PMID: 2257632, PMID: 7945274] is a small eukaryotic protein that binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). It can also, in certain circumstance promotes actin polymerisation. Profilin also binds to polyphosphoinositides such as PIP2.

Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. That region is thought to be involved in the binding to actin. This entry represents a conserved site at the N-terminal extremity of profilin. A protein structurally similar to profilin is present in the genome of variola and vaccinia viruses (gene A42R).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns