Homologous Superfamily

DNA fragmentation factor 45kDa, C-terminal (IPR027296)

Short name: DFF-C

Description

The C-terminal region of DNA fragmentation factor 45 kDa (DFF-C) consists of four alpha-helices, which are folded in a helix-packing arrangement, with alpha-2 and alpha-3 packing against a long C-terminal helix (alpha-4) [PMID: 12144788]. The main function of this region is the inhibition of DFF40 by binding to its C-terminal catalytic domain through ionic interactions, thereby inhibiting the fragmentation of DNA in the apoptotic process. In addition to blocking the DNase activity of DFF40, the C-terminal region of DFF45 is also important for the DFF40-specific folding chaperone activity, as demonstrated by the ability of DFF45 to refold DFF40 [PMID: 12144788].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY