Homologous Superfamily

Glycoside hydrolase 38, N-terminal domain superfamily (IPR027291)

Short name: Glyco_hydro_38_N_sf

Overlapping entries


This superfamily represents a structural domain found in glycoside hydrolase families 38 (GH38, e.g. alpha-mannosidase) [PMID: 12960159].

O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 38 GH38 comprises enzymes with only one known activity; alpha-mannosidase (EC: (EC:

Lysosomal alpha-mannosidase is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. The enzyme catalyses the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides, and can cleave all known types of alpha-mannosidic linkages. Defects in the gene cause lysosomal alpha-mannosidosis (AM), a lysosomal storage disease characterised by the accumulation of unbranched oligo-saccharide chains.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.