Platelet-derived growth factor receptor alpha (IPR027290)

Short name: PDGFRA

Overlapping homologous superfamilies


Family relationships



Platelet-derived growth factor (PDGF) is a growth factor that plays a significant role in cell proliferation and embryonic develpment. It is regulated through the platelet-derived growth factor receptor (PDGFR), a tyrosine kinase (RTK) [PMID: 1653029]. There are two types of PDGFR: alpha and beta. This entry represents the alpha type PDGFR (PDGFRA).

In human, there are four genes expressing PDGF chains: PDGF-A, B, C and D. They can form isoforms with each other, such as PDGF-AA, AB, BB, CC and DD [PMID: 11331881, PMID: 1709159]. PDGF isoforms bind two distinct receptors, PDGF-alpha and -beta, and this mechanism induces receptor autophosphorylation and activates signal transduction [PMID: 17656670]. PDGFR alpha acts as a receptor for homodimeric PDGF-AA, PDGF-BB and PDGF-CC and for heterodimers formed by PDGF-AB [PMID: 11331882, PMID: 8586421]. The activities of the PDGFs have been extensively studied at the molecular and cellular level and in in vivo model systems [PMID: 9285559, PMID: 21938754, PMID: 2550144, PMID: 2554309, PMID: 1653029, PMID: 1709159, PMID: 1846866, PMID: 1314164, PMID: 1396585, PMID: 1313434]. A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome [PMID: 12808148, PMID: 20972453]. Defects in PDGFRA are a cause of gastrointestinal stromal tumor [PMID: 12522257, PMID: 15928335].

GO terms

Biological Process

GO:0048008 platelet-derived growth factor receptor signaling pathway

Molecular Function

GO:0005018 platelet-derived growth factor alpha-receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.