Prostacyclin synthase (IPR027286)

Short name: PTGIS

Overlapping homologous superfamilies

Family relationships


Prostacyclin synthase (also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1) (EC: catalyses the isomerization of prostaglandin H2 to prostacyclin. It plays an important role for prostanoid biosynthesis in humans. Although it shows homology with cytochrome P450, it does not require molecular oxygen. Instead it uses its heme cofactor to catalyse the isomerization of prostaglandin H2 to prostacyclin [PMID: 6338016, PMID: 11281454].

GO terms

Biological Process

GO:0001516 prostaglandin biosynthetic process

Molecular Function

GO:0008116 prostaglandin-I synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.