Domain

Neocarzinostatin-like (IPR027273)

Short name: Neocarzinostatin-like

Domain relationships

None.

Description

Neocarzinostatin (NCS) is a member of the macromolecular antitumour antibiotic family. NCS consists of two components, a polypeptide (apo-NCS) and a nonprotein chromophore. The crystal structure of NCS is similar to that of the related chromoproteins actinoxanthin and macromomycin [PMID: 8477746].

The protein component of the chromophore displays an unusual bicyclic dienediyne structure. The chromoprotein inter-chelates the DNA, where its cycloaromatisation produces a biradical intermediate that has the ability to abstract hydrogens from the sugar moiety of DNA. This causes single- and double-strand breaks in the DNA [PMID: 11491295]. In addition to their ability to cleave DNA at sites specific for each chromophore, results indicate that these chromoproteins also possess proteolytic activity against histones, with histone H1 as the preferred substrate [PMID: 9383447].

This entry represents a domain is found in antitumour antibiotic chromoproteins from the neocarzinostatin family [PMID: 8235619] and the thiamine biosynthesis protein X.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D