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Overview
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Pathways & interactions
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Cross-references
GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 (IPR027266)
Short name: TrmE/GcvT_dom1
Overlapping entries
- Aminomethyltransferase, folate-binding domain (IPR006222)
- Glycine cleavage system T protein (IPR006223)
- Sarcosine oxidase, gamma subunit, heterotetrameric (IPR006280)
- Sarcosine oxidase, gamma subunit (IPR007375)
- GTP-binding protein TrmE, N-terminal (IPR018948)
- Glycine cleavage system T protein, bacteria (IPR022903)
- Aminomethyltransferase-like (IPR028896)
Description
This entry represents an alpha/beta domain found in GTP-binding protein TrmE (N-terminal domain) [PMID: 15616586] and domain 1 of glycine cleavage T-protein (also known as aminomethyltransferase) [PMID: 15355973].
TrmE is a guanine nucleotide-binding protein conserved between bacteria and eukaryotes. It is involved in the modification of uridine bases at the first anticodon (wobble) position of tRNAs. The N-terminal portion of the protein is necessary for mediating dimer formation within the protein [PMID: 15616586].
Glycine cleavage T-protein is part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes [PMID: 11286922]. GCV catalyses the oxidative decarboxylation of glycine. The T-protein is an aminomethyl transferase EC:2.1.2.10. The N-terminal region (residues 14-35) of domain 1 plays a crucial role in H-protein interaction [PMID: 15355973].
GO terms
Biological Process
No terms assigned in this category.
Molecular Function
GO:0005515 protein binding
Cellular Component
No terms assigned in this category.
Contributing signatures
- G3DSA:3.30.1360.120 (G3DSA:3.30.1360.120)