Homologous Superfamily

GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 (IPR027266)

Short name: TrmE/GcvT_dom1

Overlapping entries


This entry represents an alpha/beta domain found in GTP-binding protein TrmE (N-terminal domain) [PMID: 15616586] and domain 1 of glycine cleavage T-protein (also known as aminomethyltransferase) [PMID: 15355973].

TrmE is a guanine nucleotide-binding protein conserved between bacteria and eukaryotes. It is involved in the modification of uridine bases at the first anticodon (wobble) position of tRNAs. The N-terminal portion of the protein is necessary for mediating dimer formation within the protein [PMID: 15616586].

Glycine cleavage T-protein is part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes [PMID: 11286922]. GCV catalyses the oxidative decarboxylation of glycine. The T-protein is an aminomethyl transferase EC: The N-terminal region (residues 14-35) of domain 1 plays a crucial role in H-protein interaction [PMID: 15355973].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.