Mast/stem cell growth factor receptor (IPR027263)

Short name: SCGF_receptor

Overlapping homologous superfamilies


Family relationships



Mast/stem cell growth factor receptor (Kit) is a receptor protein-tyrosine kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Kit consists of an extracellular domain, a transmembrane segment, a juxtamembrane segment, and a protein kinase domain that contains an insert of about 80 amino acid residues. Binding of stem cell factor to Kit results in receptor dimerization and activation of protein kinase activity [PMID: 16129412, PMID: 7520444, PMID: 9528781, PMID: 10397721, PMID: 12444928, PMID: 12878163, PMID: 12511554, PMID: 17904548, PMID: 19265199, PMID: 21640708, PMID: 21135090].

GO terms

Biological Process

GO:0038093 Fc receptor signaling pathway
GO:0038109 Kit signaling pathway

Molecular Function

GO:0019955 cytokine binding
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.