Pathways & interactions
Mitogen-activated protein kinase kinase kinase 13 (IPR027258)
Short name: MAPKKK13
Overlapping homologous superfamilies
- Mitogen-activated protein kinase kinase kinase 12/13 (IPR017419)
- Mitogen-activated protein kinase kinase kinase 13 (IPR027258)
MAP3K13 (also known as leucine zipper-bearing kinase LZK) activates the c-Jun-NH2 terminal kinase (JNK) pathway through activation of the MAP kinase kinase MAP2K7 [PMID: 12492477, PMID: 11726277]. MAP3K13 acts synergistically with peroxiredoxin-3 (PRDX3) to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B [PMID: 12492477]. MAP3K13 forms dimers/oligomers through its dual leucine zipper-like motif, and that this is necessary for activation of the JNK/SAPK pathway [PMID: 11163770].
No terms assigned in this category.
- PIRSF500742 (MAPKKK13)