Mitogen-activated protein kinase kinase kinase 13 (IPR027258)

Short name: MAPKKK13

Overlapping homologous superfamilies


Family relationships


MAP3K13 (also known as leucine zipper-bearing kinase LZK) activates the c-Jun-NH2 terminal kinase (JNK) pathway through activation of the MAP kinase kinase MAP2K7 [PMID: 12492477, PMID: 11726277]. MAP3K13 acts synergistically with peroxiredoxin-3 (PRDX3) to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B [PMID: 12492477]. MAP3K13 forms dimers/oligomers through its dual leucine zipper-like motif, and that this is necessary for activation of the JNK/SAPK pathway [PMID: 11163770].

GO terms

Biological Process

GO:0007254 JNK cascade
GO:0000186 activation of MAPKK activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0046777 protein autophosphorylation

Molecular Function

GO:0004709 MAP kinase kinase kinase activity
GO:0042803 protein homodimerization activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.