Mitogen-activated protein kinase kinase kinase 12 (IPR027257)

Short name: MAPKKK12

Overlapping homologous superfamilies


Family relationships


MAP3K12 (also known as leucine-zipper protein kinase (ZPK), dual leucine zipper-bearing kinase (DLK) or MAPK-upstream kinase (MUK)) is a MAPKKK class protein kinase that induces JNK/SAPK activation. MAP3K12 is known to interact with MUK-binding inhibitory protein (MBIP). MBIP contains two tandem leucine-zipper-like motifs; MBIP interacts with one of the two leucine-zipper-like motifs of MAP3K12 and inhibits the activity of MAP3K12 to induce JNK/SAPK activation [PMID: 10801814, PMID: 14697235]. MAP3K12 is autophosphorylated on Ser/Thr in cytosol under basal conditions, and dephosphorylated when membrane-associated.

GO terms

Biological Process

GO:0007254 JNK cascade
GO:0000186 activation of MAPKK activity
GO:0046777 protein autophosphorylation

Molecular Function

GO:0004709 MAP kinase kinase kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.