Transcriptional enhancer factor TEF-5 (TEAD3) (IPR027253)

Short name: TEF-5

Overlapping homologous superfamilies


Family relationships


The TEAD family (also known as TEF family) transcription factors play a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD transcription factors act by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction [PMID: 18579750, PMID: 19324877].

Four TEAD genes exist in mammals (TEAD 1 to 4). TEAD3 (transcriptional enhancer factor TEF-5) has a role in placental development [PMID: 9671946].

GO terms

Biological Process

GO:0035329 hippo signaling
GO:0045944 positive regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.