Family

Mitochondrial import inner membrane translocase subunit Tim10/Tim12 (IPR027247)

Short name: Tim10/Tim12

Family relationships

Description

Tim10 is a mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane [PMID: 9430585]. It is also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane [PMID: 11483513]. It acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space [PMID: 14973126, PMID: 12138093].

Tim12 (also known as Mrs5) is essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane [PMID: 8663351]. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. In the TIM22 complex, it acts as a docking point for the soluble TIM9-TIM10 heterohexamer that guides the target proteins in transit through the aqueous mitochondrial intermembrane space [PMID: 9495346, PMID: 9430585, PMID: 10995434, PMID: 10369662].

GO terms

Biological Process

GO:0045039 protein import into mitochondrial inner membrane

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER