Cofilin 1 (IPR027234)

Short name: Cofilin_1

Overlapping homologous superfamilies

Family relationships


This entry represents cofilin 1. Cofilins bind to F-actin and exhibit pH-sensitive F-actin depolymerising activity. They are important for mitosis and plays a role in the regulation of cell morphology and cytoskeletal organisation [PMID: 15580268, PMID: 14627701]. The activities of cofilin and ADF (actin-depolymerising factor) are inhibited through phosphorylation by kinases (LIMKs and TESKs); the inactive cofilin and ADF can be re-activated through dephosphorylation by phophatases including SSH and chronophin. The proper regulation of cofilin/ADF activities through control of phosphorylation by LIMKs and SSHs is critical for neurite extension [PMID: 17360713].

GO terms

Biological Process

GO:0030042 actin filament depolymerization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0015629 actin cytoskeleton

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.