CXC chemokine 11 (IPR027221)

Short name: CXCL11

Overlapping homologous superfamilies

Family relationships


CXC chemokine 11 (CXCL11), also known as interferon-inducible T-cell alpha chemoattractant (I-TAC) or interferon gamma-inducible protein 9 (IP-9), is a cytokine belonging to the CXC chemokine family. It is chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. It induces calcium release in activated T-cells. Chemokines act through G protein-coupled, seven transmembrane domain receptors; CXCL11 binds to CXCR3 [PMID: 9625760, PMID: 10233762]. It may play an important role in CNS (central nervous system) diseases which involve T-cell recruitment [PMID: 20487305].

GO terms

Biological Process

GO:0006935 chemotaxis
GO:0006954 inflammatory response

Molecular Function

GO:0008009 chemokine activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.