Small ubiquitin-related modifier, chordates (IPR027218)

Short name: SUMO_chordates

Family relationships



This entry represents the small ubiquitin-related modifier (SUMO) proteins. SUMO share similar three-dimensional structure and the mechanism of ligation to proteins with ubiquitin. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability [PMID: 12383504]. Proteins in this entry includes small ubiquitin-related modifier 2/3/4 (SUMO2/3/4) [PMID: 9556629, PMID: 11451954, PMID: 15123604].

GO terms

Biological Process

GO:0016925 protein sumoylation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.