Toll-like receptor 1 (IPR027190)

Short name: TLR1

Overlapping homologous superfamilies

Family relationships



Toll-like receptor 1 (TLR1) participates in the innate immune response to microbial agents. TLR1 cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides [PMID: 12077222, PMID: 12091878]. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

GO terms

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0042495 detection of triacyl bacterial lipopeptide
GO:0006954 inflammatory response
GO:0042116 macrophage activation
GO:0050707 regulation of cytokine secretion
GO:0034130 toll-like receptor 1 signaling pathway

Molecular Function

GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.