Toll-like receptor 2 (IPR027185)

Short name: TLR2

Overlapping homologous superfamilies

Family relationships



Toll-like receptor 2 (TLR2) is a member of the Toll-like receptor (TLR) family, which plays a role in activation of innate immunity and pathogen recognition [PMID: 11680785]. It helps mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components, acting via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [PMID: 12610729, PMID: 17449723, PMID: 10426995, PMID: 12594207]. TLR2 in association with TLR1 or TLR6 is essential for recognising bacterial lipoproteins and lipopeptides [PMID: 11431423, PMID: 12077222]. It also promotes apoptosis in response to lipoproteins [PMID: 10426996].

Genetic variations in TLR2 are associated with susceptibility to leprosy, a chronic disease associated with depressed cellular (but not humoral) immunity [PMID: 18177245, PMID: 12646604].

GO terms

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0045087 innate immune response
GO:0050729 positive regulation of inflammatory response
GO:0050707 regulation of cytokine secretion
GO:0002237 response to molecule of bacterial origin
GO:0034134 toll-like receptor 2 signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.