Family

Monocarboxylate transporter 2 (IPR027178)

Short name: MCT2

Family relationships

Description

Monocarboxylate transporter 2, also known as SLC16A7, belongs to the MCT family. It has a higher affinity for L-lactate, pyruvate, D-beta-hydroxybutyrate and acetoacetate than MCT1 [PMID: 7829520].

Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities [PMID: 22131303]. MCT1-4 have been linked to cancer maintenance and aggressiveness [PMID: 22407107].

GO terms

Biological Process

GO:0015718 monocarboxylic acid transport
GO:1901475 pyruvate transmembrane transport

Molecular Function

GO:0008028 monocarboxylic acid transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER