Toll-like receptor 5 (IPR027176)

Short name: TLR5

Overlapping homologous superfamilies


Family relationships



Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. Toll-like receptors are classified into various types, depending on their primary sequence and types of ligands they recognise. TLR5 mediates detection of bacterial flagellins, both from from both Gram-positive and Gram-negative bacteria [PMID: 11323673, PMID: 17442957]. TLR5 signaling acts via MYD88. In MyD88-dependent signaling, ligand binding to TLR triggers sequential recruitment of MyD88, members of IRAK (interleukin-1 receptora ssociated kinase) family and TRAF6, that results in nuclear factor (NF)-kB activation and induction of cytokine secretion and production of inflammatory cytokines including IL-8 and TNF-alpha. Genetic variation in TLR5 have been associated with systemic lupus erythematosus, an inflammatory and often febrile multisystemic disorder of connective tissue [PMID: 16027372].

GO terms

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0001819 positive regulation of cytokine production
GO:0050707 regulation of cytokine secretion
GO:0034146 toll-like receptor 5 signaling pathway

Molecular Function

GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.