Toll-like receptor 8 (IPR027175)

Short name: TLR8

Overlapping homologous superfamilies

Family relationships



Toll-like receptor 8 (TLR8) is a key component of innate and adaptive immunity [PMID: 16123302, PMID: 12032557, PMID: 16188996]. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [PMID: 17932028]. TLR8 has been shown to recognise different types of ligands such as viral or bacterial ssRNA, as well as small synthetic molecules. Activation by ligands is species-specific, varying among non-rodents and rodents [PMID: 14976262, PMID: 21949866].

GO terms

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0051607 defense response to virus
GO:0006954 inflammatory response
GO:0045089 positive regulation of innate immune response
GO:0050707 regulation of cytokine secretion
GO:0034158 toll-like receptor 8 signaling pathway

Molecular Function

GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.