Toll-like receptor 3 (IPR027173)

Short name: TLR3

Overlapping homologous superfamilies

Family relationships



Toll-like receptor 3 (TLR3) is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection [PMID: 14993594, PMID: 18420935, PMID: 16144834, PMID: 16858407, PMID: 16720699, PMID: 17178723]. TLR3 assembles on dsRNA as stable dimers and the minimal signaling unit is one TLR3 dimer [PMID: 18172197].

Most TLRs signal through the MyD88-dependent pathway. However, TLR3 utilises a MyD88-independent pathway. TLR3 induces type I interferon (IFN), inflammatory cytokine/chemokine production, and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF) [PMID: 18262679].

GO terms

Biological Process

GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0051607 defense response to virus
GO:0045087 innate immune response
GO:0032722 positive regulation of chemokine production
GO:0001819 positive regulation of cytokine production
GO:0050729 positive regulation of inflammatory response
GO:0043330 response to exogenous dsRNA
GO:0034138 toll-like receptor 3 signaling pathway

Molecular Function

GO:0003725 double-stranded RNA binding
GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.