Toll-like receptor 4 (IPR027168)

Short name: TLR4

Overlapping homologous superfamilies

Family relationships



Toll-like receptor 4 (TLR4) is a member of the Toll-like receptor (TLR) family, which plays a role in activation of innate immunity and pathogen recognition [PMID: 11680785]. Although TLR4 is essential for the signalling of lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria, the response to LPS requires several additional molecules. It cooperates with LY96 and CD14 to mediate the innate immune response to LPS. It acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [PMID: 10952994]. It is also involved in LPS-independent inflammatory responses triggered by Ni2+ [PMID: 20711192].

GO terms

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0050829 defense response to Gram-negative bacterium
GO:0045087 innate immune response
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0042116 macrophage activation
GO:0050707 regulation of cytokine secretion
GO:0034142 toll-like receptor 4 signaling pathway

Molecular Function

GO:0001875 lipopolysaccharide receptor activity
GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0016021 integral component of membrane
GO:0046696 lipopolysaccharide receptor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.