Neurexin-3 (IPR027158)

Short name: NRXN3

Family relationships



The neurexins are a family of proteins that function in the nervous system as cell adhesion molecules and receptors [PMID: 9448462], which have a role in synaptogenesis [PMID: 19738623]. In mammals, the neurexins are encoded by three genes, NRXN1, NRXN2, and NRXN3, that may express over 1000 isoforms. Each gene encodes two major isoforms designated alpha and beta. Neurexins are also found in non-vertebrate species, including those from bilatieria and in cnindarians. In addition, they are found in are also found in porifera, but their function in these organisms is unclear [PMID: 19738623].

Alpha-neurexins have a role in organising synapse assembly and synaptic signal transmission Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions [PMID: 20064388, PMID: 12827191, PMID: 9430716, PMID: 21356198].

This entry represents Neurexin-3.

GO terms

Biological Process

GO:0007269 neurotransmitter secretion
GO:0051965 positive regulation of synapse assembly
GO:0090129 positive regulation of synapse maturation
GO:0007416 synapse assembly
GO:0007268 synaptic transmission

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.