Hephaestin (IPR027154)

Short name: HEPH

Overlapping homologous superfamilies


Family relationships



Hephaestin (HEPH) is a membrane-bound ceruloplasmin homologue that plays a critical role in intestinal iron absorption [PMID: 11557513, PMID: 11932491, PMID: 9988272]. It may function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis [PMID: 10697391, PMID: 16274220]. Hephaestin interacts with another protein involved in intestinal iron absorption, ferroportin 1 [PMID: 17486601, PMID: 18974313, PMID: 21473866]. In mouse, defects in HEPH can lead to severe microcytic hypochronic anemia [PMID: 9988272]. .

GO terms

Biological Process

GO:0006879 cellular iron ion homeostasis
GO:0006826 iron ion transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005886 plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.