Ceruloplasmin (IPR027150)

Short name: CP

Overlapping homologous superfamilies


Family relationships



Ceruloplasmin (CP) is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Ceruloplasmin may also play a role in fetal lung development or pulmonary antioxidant defence. It provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 [PMID: 14707133, PMID: 12055353, PMID: 17242517]. Defects in CP cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities [PMID: 22343016].

GO terms

Biological Process

GO:0006879 cellular iron ion homeostasis
GO:0006825 copper ion transport

Molecular Function

GO:0005507 copper ion binding
GO:0004322 ferroxidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.