Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 (IPR027141)

Short name: LSm4/Sm_D1/D3

Overlapping homologous superfamilies

Family relationships


This entry represents a group of LSM domain containing proteins functioning in RNA processing, including U6 snRNA-associated Sm-like protein LSm4 and small nuclear ribonucleoproteins Sm D1 and D3.

LSm4 is a component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. It binds specifically to the 3'-terminal U-tract of U6 snRNA [PMID: 10747033, PMID: 12077351].

SmD1 is involved in pre-mRNA splicing. It binds snRNA U1, U2, U4 and U5, which contain a highly conserved structural motif called the Sm binding site. It also binds telomerase RNA and is required for its accumulation [PMID: 8430095, PMID: 10490028].

SmD3 is a core protein of small nuclear ribonucleoprotein (snRNP) essential for splicing of primary transcripts [PMID: 21421416]. It appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. It binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner [PMID: 11574479].

GO terms

Biological Process

GO:0006396 RNA processing

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.