TNF receptor-associated factor 3 (IPR027128)

Short name: TRAF3

Family relationships


Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein (MAP) kinase activation and non-canonical nuclear factor-kB signalling [PMID: 21660053]. It is a critical regulator of both innate and adaptive immune responses [PMID: 17633016]. TRAF3 plays a role in the regulation of B-cell survival [PMID: 18313334], in the regulation of antiviral responses [PMID: 16306936], and in T-cell dependent immune responses [PMID: 8934568]. It is required for normal antibody isotype switching from IgM to IgG [PMID: 19228877]. Differences in the ubiquitination of TRAF3 are the key to the selective production of type I interferons versus proinflammatory cytokines [PMID: 19898473].

GO terms

Biological Process

GO:0008063 Toll signaling pathway
GO:0045087 innate immune response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0001817 regulation of cytokine production
GO:0050688 regulation of defense response to virus
GO:0033209 tumor necrosis factor-mediated signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.