Platelet-derived growth factor D (IPR027123)

Short name: PDGFD

Overlapping homologous superfamilies


Family relationships



Platelet-derived growth factor (PDGF) belongs to the PDGF/VEGF growth factor family, which are major mitogens for many types of cells and play an important role in angiogenesis and wound healing [PMID: 18055825]. There are four PDGF isoforms: PDGF-A, -B, -C, which form homodimers or heterodimers (PDGF-AA, -BB, -AB, -CC, and -DD).

This entry presents PDGFD, which plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. PDGFD induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis [PMID: 11331881, PMID: 15271796].

GO terms

Biological Process

GO:0048008 platelet-derived growth factor receptor signaling pathway

Molecular Function

GO:0005161 platelet-derived growth factor receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.