Family

Vacuolar protein sorting-associated protein 33 (IPR027121)

Short name: VPS33

Family relationships

  • Sec1-like protein (IPR001619)
    • Vacuolar protein sorting-associated protein 33 (IPR027121)

Description

Vacuolar protein sorting-associated protein 33 (Vps33) is essential for vacuolar biogenesis, maturation and function. It is involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole [PMID: 12868054]. In worm, fly, zebrafish and mammals two homologues of yeast Vps33p have been detected (termed VPS33A and VPS33B in humans). These homologues may reflect the evolution of organelle/tissue-specific functions in multicellular organisms. It is thought that VPS33B may be required for transport to conventional lysosomes, while VPS33A is mainly involved in biogenesis of melanosomes and related lysosomal compartments [PMID: 12538872, PMID: 15790593].

GO terms

Biological Process

GO:0016192 vesicle-mediated transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PANTHER