Family

U4/U6 small nuclear ribonucleoprotein Prp3 (IPR027104)

Short name: Prp3

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Prp3 (also known as PRP3) participates in pre-mRNA splicing [PMID: 9328476]. It may play a role in the assembly of the U4/U5/U6 tri-snRNP complex [PMID: 9326489]. Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18). RP leads to degeneration of retinal photoreceptor cells [PMID: 11773002, PMID: 12714658, PMID: 17932117]. In Arabidposis thaliana, protein RDM16 acts as a pre-mRNA splicing factor and functions in RNA-directed DNA methylation by influencing Pol V transcript levels [PMID: 24068953].

GO terms

Biological Process

GO:0000398 mRNA splicing, via spliceosome

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0046540 U4/U6 x U5 tri-snRNP complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER