Secreted Ly-6/uPAR-related protein 1 (IPR027103)

Short name: SLURP1

Overlapping homologous superfamilies


Family relationships



Secreted Ly-6/uPAR-related protein 1 (SLURP-1) belongs to the Ly-6/uPAR superfamily of receptor and secreted proteins. SLURP1 has antitumor activity. It was found to be a marker of late differentiation of the skin. SLURP1 is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin [PMID: 16354194, PMID: 14721776, PMID: 17008884]. Defects in SLURP1 are a cause of Mal de Meleda (MDM); also known as keratosis palmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterised by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens) [PMID: 17008884, PMID: 11285253].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.