Sodium channel subunit beta-1/beta-3 (IPR027098)

Short name: Na_channel_b1/b3

Overlapping homologous superfamilies

Family relationships


The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 and beta-3 subunits. Subunit beta-1 is crucial in the assembly, expression, and functional modulation of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart [PMID: 8125980, PMID: 14622265].

Both beta-1 and beta-3 associate with neurofascin through their extracellular immunoglobulin-like domains. This association may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons [PMID: 11470829].

GO terms

Biological Process

GO:0006814 sodium ion transport

Molecular Function

GO:0017080 sodium channel regulator activity

Cellular Component

GO:0001518 voltage-gated sodium channel complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.