Mitotic spindle checkpoint protein Mad2 (IPR027097)

Short name: Mad2

Overlapping homologous superfamilies

Family relationships



Mad2 is a central component of the spindle assembly checkpoint, which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis [PMID: 8232541, PMID: 15879521]. In Saccharomyces cerevisiae, it is a component of the mitotic checkpoint complex (MCC) which consists of MAD2, MAD3, BUB3 and CDC20, and of the MAD2-CDC20 subcomplex, both of which appear to be assembled during mitoisis independently of the kinetochore. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 [PMID: 15879521, PMID: 11726501, PMID: 10436016].

GO terms

Biological Process

GO:0007094 mitotic spindle assembly checkpoint

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.