EAF family (IPR027093)

Short name: EAF_fam

Overlapping homologous superfamilies


Family relationships



This entry represents the ELL-associated factor (Eaf) family of proteins. They interact with ELL and ELL2, which are RNA polymerase II elongation factors. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation [PMID: 11418481]. ELL and EAF1 are components of Cajal bodies, which have a role in leukemogenesis [PMID: 12686606].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0032783 ELL-EAF complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.