Serine/threonine-protein kinase TOUSLED-like 2 (IPR027086)

Short name: TLK2

Overlapping homologous superfamilies


Family relationships



This entry represents the serine/threonine-protein kinase TOUSLED- like 2 (TLK2) protein (EC:

TLK2 is involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. It phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. It acts as a negative regulator of amino acid starvation-induced autophagy [PMID: 10092119].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.