Protein kinase Mps1 family (IPR027084)

Short name: Prot_kin_Mps1_fam

Overlapping homologous superfamilies


Family relationships


The Mps1 family of protein kinases is a critical regulator of genetic stability [PMID: 14963409, PMID: 12214245]. In yeast, Mps1 is required for the spindle checkpoint and SPB duplication [PMID: 11827982]. Human Mps1, also known as TTK, is required for proper chromosome alignment on the metaphase plate and for the fidelity of chromosome segregation, and might also have a role at centrosomes [PMID: 23226601]. It is associated with cell proliferation and involved in mitotic cell cycle checkpoint control [PMID: 12399306, PMID: 15231734]. In late mitosis, Mps1 is ubiquitinated by the APC/C and subsequently degraded [PMID: 20729194]. The catalytic domain of Mps1 is in the C-terminal region, and the N-terminal region includes TPR repeats that promote homodimer formation [PMID: 22187426].

GO terms

Biological Process

GO:0051304 chromosome separation
GO:0007093 mitotic cell cycle checkpoint

Molecular Function

GO:0004712 protein serine/threonine/tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.