CyclinH/Ccl1 (IPR027081)

Short name: CyclinH/Ccl1

Overlapping homologous superfamilies

Family relationships



Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [PMID: 12910258], and regulate cyclin dependent kinases (CDKs).

This entry includes cyclin-H from vertebrates, mcs2 from fission yeast and Ccl1 from budding yeasts. They are cyclins that play a role in cell cycle. They are also subunits forming the core-TFIIH basal transcription factor. Human cyclin-H regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex [PMID: 16769902]. mcs2 posseses kinase activity that can be detected when myelin basic protein (MBP) is provided as an exogenous substrate [PMID: 8467814]. Ccl1 is a regulatory component of the TFIIK complex, which is the protein kinase component of transcription factor IIH (TFIIH). TFIIH is essential for both basal and activated transcription and is involved in nucleotide excision repair (NER) of damaged DNA and in polymerase II transcription [PMID: 9235928].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity

Cellular Component

GO:0070985 TFIIK complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.