Protein Unc-13 (IPR027080)

Short name: Unc-13

Overlapping homologous superfamilies


Family relationships


Unc-13 is a phorbol ester/diacylglycerol-binding protein that plays a role in vesicle maturation during exocytosis [PMID: 10233166, PMID: 9697857]. Unc-13 disruption causes diverse defects in the nervous system of the nematode Caenorhabditis elegans [PMID: 2062851, PMID: 1445255]. This family also includes mammalian homologues A, B and C [PMID: 7559667]. Unc13 homologue C is cerebellum-specific and regulates cerebellar synaptic transmission [PMID: 11150314]. Homologues A and B are involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion [PMID: 12070347]. They are essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses [PMID: 10440375].

GO terms

Biological Process

GO:0007268 chemical synaptic transmission

Molecular Function

GO:0019992 diacylglycerol binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.