TFIIH subunit Tfb1/GTF2H1 (IPR027079)

Short name: Tfb1/GTF2H1

Overlapping homologous superfamilies


Family relationships



TFIIH is a eukaryotic complex composed of two subcomplexes, the CAK (Cdk activating kinase) and the core-TFIIH. This entry represents Tfb1/GTF2H1, a component of the core-TFIIH basal transcription factor, which consists of seven subunits known as XPB, XPD, GTF2H1 (p62), p52, p44, p34, and p8 in humans and Ssl2, Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and Tfb5 in yeast [PMID: 23147676]. TFIIH is involved in nucleotide excision repair (NER) of DNA and RNA transcription by RNA polymerase II and I [PMID: 7891722, PMID: 12015980, PMID: 14550632].

GO terms

Biological Process

GO:0006289 nucleotide-excision repair
GO:0006351 transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000439 core TFIIH complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.