Small nuclear ribonucleoprotein E (IPR027078)

Short name: snRNP-E

Family relationships



Small nuclear ribonucleoprotein E (SME1) is involved in pre-mRNA splicing. It is required for pre-mRNA splicing, cap modification and for the stability of snRNA U1, U2, U4 and U5 [PMID: 8918241, PMID: 15916535].

Splicing of nuclear pre-mRNA in yeasts and mammals occurs in the spliceosome which contains U1, U2, U4/U6 and U5 small nuclear ribonucleoprotein particles. They consist of the common core proteins, also known as Sm proteins, (B/B', D1, D2, D3, E, F, G), which bind to a highly conserved structural motif called -the Sm site- present in U1, U2, U4 and U5 snRNAs. The Sm ring complex is required for the biogenesis of the U1, U2, U4, and U5 snRNPs and also has additional functions during splicing of nuclear mRNAs [PMID: 7799953].

GO terms

Biological Process

GO:0000398 mRNA splicing, via spliceosome

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005681 spliceosomal complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.