Cleavage and polyadenylation specificity factor subunit 2 (IPR027075)

Short name: CPSF2

Overlapping homologous superfamilies

Family relationships



Cleavage and polyadenylation specificity factor (CPSF) plays a key role in pre-mRNA 3'-end formation, recognising the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition [PMID: 14749727].

This entry represents the 100-kilodalton subunit (subunit 2) [PMID: 7969155]. In Xenopus laevis this subunit seems to be predominantly involved in cytoplasmic polyadenylation reaction [PMID: 10409759].

GO terms

Biological Process

GO:0006379 mRNA cleavage
GO:0006378 mRNA polyadenylation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005847 mRNA cleavage and polyadenylation specificity factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.