Pathways & interactions
Integrin beta-1 subunit (IPR027071)
Short name: Integrin_beta-1
- Integrin beta subunit (IPR015812)
- Integrin beta-1 subunit (IPR027071)
Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [PMID: 12297042, PMID: 12361595]. The integrin receptors are composed of alpha and beta subunit heterodimers. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.
Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits [PMID: 12234368]. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans [PMID: 14689578]. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule [PMID: 2467745]. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.
This entry represent integrin beta-1. Beta-1 integrin associates with alpha subunits to form receptor complexes that bind a variety of ligands. Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Alpha7beta1 integrin regulates cell adhesion and laminin matrix deposition [PMID: 12941630]. Integrin alpha-4/beta-1 is a receptor for VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4 and has a role in endothelial cell motility and angiogenesis [PMID: 15181153].
- PTHR10082:SF28 (PTHR10082:SF28)