Family

Integrin beta-3 subunit (IPR027068)

Short name: Integrin_beta-3

Overlapping homologous superfamilies

None.

Family relationships

Description

Integrins function as a heterodimer composed of an alpha and a beta chain. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. In humans, there are 8 different alpha chains and 18 different beta chains which by multiple combinations of dimerization make at least 24 different alpha/beta heterodimers [PMID: 22984613].

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognise the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognises the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface [PMID: 2341395, PMID: 9195946, PMID: 29470988]. Integrin beta-3 has also been shown to play an important role in cardiosphere attachment to fibronectin in the heart [PMID: 29024385].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0070527 platelet aggregation

Molecular Function

GO:0005178 integrin binding

Cellular Component

GO:0008305 integrin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER