Ran GTPase-activating protein (IPR027038)

Short name: RanGap

Overlapping homologous superfamilies

Family relationships



Ran GTPase-activating protein (RanGap) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state [PMID: 9442102, PMID: 9456312, PMID: 16469311]. RanGap is an antagonist of RCC1, a nuclear protein that converts RanGDP to RanGTP and keep Ran in an active state. Together, they control Ran dependent transport between the nucleus and cytoplasm [PMID: 8896452]. In human, RanGap is regulated by sumoylation and phosphorylation through the cell cycle [PMID: 15037602, PMID: 11854305].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.