Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 (IPR027031)

Short name: Gly-tRNA_synthase/POLG2

Overlapping homologous superfamilies


Family relationships


This family includes both Glycyl-tRNA synthetases and mitochondrial DNA polymerase subunit gamma-2 (POLG2).

Glycyl-tRNA synthetase catalyses the attachment of glycine to tRNA(Gly). The DNA polymerase gamma-2 subunit acts as a processivity factor to stimulate the catalytic subunit of DNA polymerase gamma. Pol gamma-2 shares conserved sequence blocks with prokaryotic class II aminoacyl-tRNA synthetases, and these are necessary for activity and inter-action with the catalytic subunit [PMID: 10666468].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.