GOSR2/Membrin/Bos1 (IPR027027)

Short name: GOSR2/Membrin/Bos1

Family relationships



This entry consists of the Golgi SNAP receptor complex member 2 (GOSR2) and the related proteins membrin (Memb11 and Memb12) in plants and Bos1 in yeasts.

Bos1 is a vesicle specific SNAP receptor (v-SNARE), which is necessary for vesicular transport from the ER to the Golgi [PMID: 10547372]. GOSR2 is found involved in protein transport through the Golgi apparatus [PMID: 9349823]. In Arabidopsis, Memb11 is a v-SNARE involved in anterograde protein trafficking at the ER-Golgi interface [PMID: 16244155].

In human, defects in GOSR2 are the cause of progressive myoclonic epilepsy type 6 (EPM6). A neurologic disorder characterised by onset of ataxia in the first years of life, followed by action myoclonus and seizures later in childhood, and loss of independent ambulation in the second decade [PMID: 21549339].

GO terms

Biological Process

GO:0006810 transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005795 Golgi stack

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.