Kinesin-like protein KIF22 (Kid) (IPR026986)

Short name: KIF22

Overlapping homologous superfamilies

Family relationships


Kinesin-like protein KIF22 (also known as kinesin-like DNA-binding protein, Kid) is a chromokinesin that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis [PMID: 10966104, PMID: 10966105, PMID: 12360284]. KIF22 is associated with chromosome arms and plays an important part in producing the polar ejection forces that move chromosome arms toward the spindle equator at metaphase during mitosis [PMID: 10966105]. Its destruction is needed for anaphase chromosome movement [PMID: 10966104]. Depletion of KIF22 caused abnormal chromosome arm orientation, delayed chromosome congression, and sensitised cells to nocodazole [PMID: 22945934].

Defects in KIF22 are the cause of spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2), a bone disease characterised by short stature, distinctive midface retrusion, progressive knee malalignment, generalised ligamentous laxity, and mild spinal deformity [PMID: 22152677, PMID: 22152678].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.