Family

Condensin subunit 1/Condensin-2 complex subunit D3 (IPR026971)

Short name: CND1/NCAPD3

Family relationships

Description

This entry includes condensin subunit 1 (CND1) and condensin-2 complex subunit D3 (NCAPD3).

CND1 is a regulatory subunit of the condensin complex (contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG), a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes [PMID: 12138188]. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases [PMID: 11854418, PMID: 9774278, PMID: 11136719].

NCAPD3 is a regulatory subunit of the condensin-2 complex (contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2) , a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis [PMID: 14532007].

GO terms

Biological Process

GO:0007076 mitotic chromosome condensation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER