Pathways & interactions
Katanin p80 subunit B1 (IPR026962)
Short name: Katanin_bsu1
This entry represents the katanin p80 WD40 repeat-containing subunit B1.
The microtubule-severing protein katanin consists of a heterodimer of 60 and 80 kDa subunits. p60 has microtubule-stimulated ATPase and microtubule-severing activities, while p80 is a novel protein containing WD40 repeats, which are frequently involved in protein-protein interactions.
Katanin p80 WD40-containing subunit B1 may act to target p60 to sites of action such as the centrosome [PMID: 9568719]. Microtubule severing may promote rapid reorganisation of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. There is also evidence that katanin localises at the leading edge of migratory cells and trims microtubules at their dynamic plus ends [PMID: 21549946].
The C-terminal domain of p80 katanin binds microtubules in vitro, while the N-terminal WD40 domain acts as a negative regulator of microtubule disassembly activity [PMID: 10751153].
- MF_03022 (Katanin_p80_B1)