F-box only protein 31 (IPR026941)
Short name: FBXO31
Overlapping homologous superfamilies
F-box only protein 31 is a component of the SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognises phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest [PMID: 16357137, PMID: 19412162].
GO:0030332 cyclin binding
GO:0019005 SCF ubiquitin ligase complex
- PTHR10706:SF126 (PTHR10706:SF126)