Family

F-box only protein 31 (IPR026941)

Short name: FBXO31

Family relationships

None.

Description

F-box only protein 31 is a component of the SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognises phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest [PMID: 16357137, PMID: 19412162].

GO terms

Biological Process

GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0031571 mitotic G1 DNA damage checkpoint

Molecular Function

GO:0030332 cyclin binding

Cellular Component

GO:0019005 SCF ubiquitin ligase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER